Emergence of native peptide sequences in prebiotic replication networks

In a recent paper in Nature Communications, collaborator Gonen Ashkenasy and co-workers report on their continued investigations related to the origin of life, analyzing a complex web of reactions in β-sheet peptide networks, and focusing on the formation of specific intermediate compounds and template-assisted replication. Specifically, they show that the enrichment of one ‘‘master sequence’’ is a result of a collective network behavior manifested by multiple template-assisted processes. They suggest that their findings may shed light on molecular evolution processes that led to current biology.

J. Nanda, B. Rubinov, D. Ivnitski, R. Mukherjee, E. Shtelman, Y. Motro, Y. Miller, N. Wagner, R. Cohen-Luria and G. Ashkenasy. Emergence of native peptide sequences in prebiotic replication networks. Nature Communications 8: 434, 2017.

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